对氯苄基四氢小檗碱氯化盐光学异构体的结构确证

崔荣，张灿，林云，华维一

(中国药科大学新药研究中心,南京)

摘要  目的: 确证对氯苄基四氢小檗碱氯化盐的四个光学异构体的结构。方法：通过对对氯苄基四氢小檗碱氯化盐四个光学异构体的氢谱(¹H NMR)、碳谱(¹³C NMR、DEPT135)、氢-氢相关谱(¹H-¹H COSY)、碳氢相关谱(HMQC)、碳氢远程相关谱(HMBC)的解析,对所有的¹H NMR、¹³C NMR谱的信号进行了归属。结果与结论:确证了对氯苄基四氢小檗碱氯化盐的四个光学异构体的光学结构。

关键词 对氯苄基四氢小檗碱,光学异构体, 结构确证

Characterization of N-p-chlorobenzyl tetrahydrobeberine chloride isomers

ZHANG Can,CUI Rong,LIN Yun HUA Wei-Yi

(College of Pharmacy,China Pharmaceutical University,Nanjing 210009)

[ABSTRACT]  AIM: To characterize the structure of N-p-chlorobenzyl tetrahydrobeberine chloride four isomers.METHOD:¹H nuclear magnetic resonance,¹³C nuclear magnetic resonance(DEPT-135),¹H-¹H correlated spectroscopy(¹H-¹HCOSY),(¹H-detected)heteronuclear multiple-quantum coherece(HMQC),(¹H-detected)heteronuclear multiple bond coherence(HMBC) of N-p-chlorobenzyl tetrahydrobeberine chloride isomers were interpreted.All the ¹H NMR and ¹³C NMR chemical shifts were assigned by means of ¹H-¹HCOSY、HMQC and HMBC.