邢俊杰  赵金晶  吴桂平 (沈阳医学院附属二院 沈阳110002) 马铁民(北京大学医学部)

摘　要　目的:　探讨缬沙坦对肾性高血压大鼠血管内皮细胞的保护作用。方法: 包埋左肾制备高血压大鼠模型，给予缬沙坦治疗5周，尾容积法测动物血压，观察缬沙坦组与高血压组血压变化并应用多导电生理记录仪描记心电图，放免法测定各组血浆血管紧张素(angiot－ensin ,AngⅡ)和内皮素(endothelin， ET-1)水平,硝酸还原酶法测定一氧化氮(nitrico－xide,NO)水平。结果: 缬沙坦可使肾性高血压大鼠血压回降84％,血浆血管紧张素Ⅱ含量升高26.2％,血浆一氧化氮含量升高64.4％，内皮素含量下降49.1％(P<0.01)。缬沙坦组与高血压组心率变异各指标无明显差异(P >0.05)。结论: 缬沙坦通过促进内皮细胞分泌NO，抑制内皮细胞分泌内皮素，对肾性高血压大鼠血管内皮细胞功能具有保护作用。

关键词　高血压　缬沙坦  血管紧张素　一氧化氮 内皮素

Protective effects of valsartan on  endothelion  in rats with renal hypertension

Xing Junjie  Zhao Jinjing    Wu Guiping（The Second Affiliated Hospital ，Shenyang Medical College ，Shenyang 110002 P.R. China）   Ma Tiemin (Beijing University Health Science Center)

ABSTRACT　Objective: To explore the protective effect of valsartan on endothel- ion  in rats with renal hypertension . Method:  Make the rats model with renal hypertension ， the rats were treated with valsartan  for 5 weeks, Record the blood pressure and ECG. The plasma levels of NO,AngⅡ and ET were measured in each group . Result: The level of plasma AngⅡand ET with hypertension were significantly higher(P <0.01),but the plasma NO level was lower than those of controls(P<0.01).In rats with hypertension, the SBP  were significantly lowered(P<0.01), the plasma  level of  AngⅡand NO increased(P<0.01) after the treatment of valsartan ,and the plasma level of ET decreased. Conclusion: The treatment of valsartan  plays an important role in protecting the endothelial function through  inhibiting endothelin excreting ET and promoting  endothelin excreting NO.

KEY WORDS　 Hypertension　valsartan　angiotensin  nitric oxide Endothelin