潘  雪  英

（常州卫生学校  江苏  常州  213003）

摘  要  目的：探讨大生产中雄黄炮制及含雄黄制剂炮制过程中的最佳烘干温度。方法：采用中国药典二乙基二硫代氨基甲酸银法，对不同干燥温度下雄黄粉中三氧化二砷(As₂O₃) 的含量进行测定。结果：60℃以下的烘烤温度对雄黄中As₂O₃含量几乎没有影响，80℃开始有变化，至180℃以上As₂O₃的含量急剧增加。结论：雄黄及雄黄制剂的加工过程中温度应控制在60℃以下；雄黄的炮制工艺还需进一步完善。

关键词  雄黄；三氧化二砷；水磨粉

Influence of Temperature on the Content of Arsenic Trioxide in Realgar

Pan Xueying (Changzhou Hygiene School, Changzhou, Jiangsu Province, 213003, P. R. China)

ABSTRACT Objective: To discuss the best drying temperature during the course of processing realgar and making realgar preparation in mass manufacture. Method: The content of arsenic trioxide in realgar power under different dry temperatures were determined by silver diethyldithio-carbamate method of Chinese Pharmacopoeia (2000). Result: There was no influence on the content of arsenic trioxide in realgar when the temperature was under 60℃. A little change happened when the temperature came to 80℃ and the content of arsenic trioxide increased greatly when the temperature was above 180℃. Conclusion: During the process of realgar, the temperature should be controlled under 60℃. The technology of realgar preparation should be further perfected.

Key words Realgar; Arsenic Trioxide; Grind grain with water