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噬菌体抗菌分子机制及临床应用研究进展-06.8

阅读: 时间: 2006-9-14 18:59:00

噬菌体抗菌分子机制及临床应用研究进展

肖非  石瑛  黄加权 

关键词:噬菌体;抗菌;hollin蛋白;内溶素;溶解蛋白
分类号:R978.1  文献标识码:A
文章编号:1008-049X(2006)08-0754-03

  噬菌体(phage)是1917年由法国的d'Herelle率先发现的,它没有独立的代谢酶系,只能利用宿主细胞的生物合成机构进行核酸复制和蛋白合成以完成自身的增殖.除丝状噬菌体因其特殊的形态能从宿主逸出而不对宿主造成致命的后果外,其它所有噬菌体都在感染周期的晚期以特定的方式溶解宿主细胞,释放子代噬菌体颗粒去感染新的宿主.……

作者单位:肖非(华中科技大学同济医学院附属同济医院感染科,武汉,430030) 
     石瑛(华中科技大学同济医学院附属协和医院泌尿外科) 
     黄加权(华中科技大学同济医学院附属同济医院感染科,武汉,430030) 

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收稿日期:2005年6月22日

修稿日期:2006年3月10日

出版日期:2006年8月5日

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