杨红武 闵江莉 吴佳 周一平杨惠芳（湖北省医药工业研究院有限公司 武汉 430061）
摘 要 目的：观察肾炎四味颗粒对肾小球肾炎的防护、对水负荷动物的利尿，对急性肾损伤的防护作用及对免疫功能的影响。方法：
采用大鼠和小鼠注射同种肾抗原性物质引起病变，作为动物模型来观察其对该模型肾炎的防护作用。结果：肾炎四味颗粒能显著地减少
Heymann肾小球肾炎模型大鼠不同时期的尿蛋白含量、降低血液尿素氮和肌酐值（P﹤0.05或P﹤0.01），对水负荷大鼠有明显的利尿作用
（P﹤0.05），对氯化高汞所致的大鼠少尿有明显增加尿量的作用（P﹤0.05），还能显著阻止血液尿素氮和肌酐的上升（P﹤0.05或P﹤
0.01），能显著激活小鼠腹腔巨噬细胞的吞噬功能（P﹤0.05），但对环磷酰胺引起的小鼠半数溶血值下降有极明显的抑制作用。结论：
本品具有活血化瘀，清热解毒，补肾益气。用于慢性肾炎。
关键词：肾炎四味颗粒；水负荷动物；肾损伤；免疫功能；肾小球肾炎
Experimental Stuty on Pharmacological Effects of Shenyansiwei Granules
Yang Hongwu，Min Jiangli，Wu Jia，Zhou YiPing，Yang HuiFang （Hubei Pharmaceatical Industry Institute Co.，Ltd.Wuhan 430061，China）
ABSTRACT Objective：To observe the protective effects of shenyansiwei granules（SG）on glomerulonephritis，acute renal injury and immune function in animals。
Method：The renal protective effects of SG were studied in the models of glomerulonephritis induced by Heymann antigen，water-loaded and acute renal injury induced by HgCl2 in rats。The immunity modulating effect of SG weredetected by the rate of abdominal phagocytosis of macrophage in normal mice and the contents of serum hemolysin（HC50）both in normal and immune suppressed mice induced by Cyclphosphamide（Cy）。Result：SG could obviously decrease the urinary protein，BUN and Cr in glomerulonephritis rats（P﹤0.05 or P﹤0.01），diuretic in water-loaded rats（P﹤0.05）and increase the urine volum（P﹤0.05），decrease the BUN and Cr of rats with glomerulonephritis（P﹤0.05 or P﹤0.01）in the acute injuryrats induced by mercury mercury crloride。SG could evidently activate the phagocytosis of peritoneal macrophage in normal mice and inhibit the decrease of HC50 in mice treated with CY。Conclusion：SG were shown to have the effects of activating blood circulation to removing blood stasis，clearing away heat and toxic material and supplementing kidney and benefiting ventilation，which could be used for the treatment of chronic nephritis。
KEY WORDS Shenyansiwei granules；Water-loaded；Kidney injury；Immunologic function； Glomerulonephritis