金剑 肖忠革 金芝贵 吴飞华 (上海交通大学医学院附属第九人民医院药剂科 上海 200011)
关键词 帕金森病；药物治疗
中图分类号：R742.5
文献标识码：A
文章编号：1008-049X(2007)03-0243-03
帕金森病(Parkinson's disease,PD)是一种常见的进行性中枢神经变性疾病，好发于中老年人，随着老龄化社会的到来，我国PD的发病率不断增高。由于对PD发病机制认识的不断深入，越来越多的药物应用于治疗PD，本文就近年来有关PD的药物治疗进展进行综述……
作者简介：金剑，男，学士，药师，执业药师. 研究方向：临床药学。
Tel：（021）63138341-5295
E-mail:ausword@126.com
参 考 文 献
1陈海波.帕金森病药物治疗目前存在的问题［J］.药物不良反应杂志,2005,7(3):161-164
2姚尧,杜俊蓉.帕金森病的药物治疗进展［J］.中国临床药理学与治疗学,2005,10(4):367-370
3 张文记,陈海波,蒋雨平,等.金刚烷胺单用及与复方丹参或丙炔苯丙胺合用治疗早期帕金森病的临床观察［J］.中国康复理论与实践,2004,10(7):418-420
4 Grosset K,Grosset D, Lees A, et al. Trial of subtherapeutic pergolide in de novo Parkinson's disease［J］. Mov Disord, 2005,20(3):363-366
5 杨昆胜,祁国兴.多巴胺受体激动剂与左旋多巴联合应用对帕金森病［J］.现代康复,2000,4(12): 1794-1795
6 Kikuchi S. Treatment for patients with early Parkinson's disease［J］.Nippon Rinsho, 2004, 62(9):1701-1708
7 Moller JC,Oertel WH,Koster J,et al. Long-term efficacy and safety of pramipexole in advanced Parkinson's disease: results from a European multicenter trial［J］.Mov Disord,2005, 20(5):602-610
8 Navan P, Findley LJ,Undy MB, et al. A randomly assigned double-blind cross-over study examining the relative anti-parkinsonian tremor effects of pramipexole and pergolide［J］. Eur J Neurol,2005,12(1):1-8
9 Matheson AJ,Spencer CM. Ropinirole:a review of its use the management of Parkinson'disease［J］.Drug,2000,60(1):115-137
10 赵鹏,张本恕,肖颖,等. 盐酸司来吉兰治疗早期帕金森病的疗效观察［J］.临床神经病学杂志,2005,18(4):306-307
11 Parkinson Study Group. A randomized placebo-controlled trial of rasagiline in levodopatreated patients with Parkinson disease and motor fluctuations: the PRESTO study［J］. Arch Neurol,2005,62(2):241-248
12 Rascol O, Brooks DJ, Melamed E, et al. Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallel-group trial［J］.Lancet, 2005,365(9463):947-954
13 张振馨,李辉,罗毅,等. 恩他卡朋治疗帕金森病的多中心、随机、双盲、安慰剂对照临床研究［J］. 中华神经科杂志 ,2003,36(6):406-410
14 Reichmann H, Boas J, Macmahon D, et al.Efficacy of combining levodopa with entacapone on quality of life and activities of daily living in patients experiencing wearingoff type fluctuations［J］. Acta Neurol Scand, 2005 ,111(1):21-28
15 Shiozaki S,Ichikawa S,Nakamura J,et al.Actions of adenosine A"2a receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP［J］. Psychopharmacology,1999,147(1):90-95
16裴正斌,彭国光.神经营养因子与帕金森病［J］.国外医学·内科学分册,2004,31(6):252-255
17 Mancini F,Zangaglia R,Cristina S,et al. Double-blind, placebo-controlled study to evaluate the efficacy and safety of botulinum toxin type A in the treatment of drooling in parkinsonism［J］. Mov Disord,2003 ,18(6):685-688
18 Obinu MC,Reibaud M,Blanchard V,et al. Neuroprotective effect of riluzole in a primate model of Parkinson's disease: behavioral and histological evidence［J］.Mov Disord,2002 ,17(1):13-19
19 Muramatsu Y, Araki T. Glial Cells as a Target for the Development of New Therapies for Treating Parkinson's Disease［J］. Drug News Perspect,2002 ,15(9):586-590
20 Ondo WG,Fayle R,Atassi F,et al.Modafinil for daytime somnolence in Parkinson's disease: double blind, placebo controlled parallel trial［J］.J-Neurol-Neurosurg Psychiatry,2005,76(12):1636-1639
21 Ravina B,Putt M,Siderowf A，et al. Donepezil for dementia in Parkinson's disease: a randomised, double blind, placebo controlled, crossover study［J］. J Neurol Neurosurg Psychiatry,2005 ,76(7):934-939
22 Emre M,Aarsland D,Albanese A, et al. Rivastigmine for dementia associated with Parkinson's disease［J］. N Engl J Med, 2004,351(24):2509-2518 资料来自:中国药师-专业站 |