陈亮 童旭 (第三军医大学大坪医院野战外科研究所药剂科 重庆 400042)
摘 要 目的：制备苯乙烯系强酸型阳离子交换树脂度米芬复合物，并测定度米芬最大吸附量。方法：均匀设计优化度米芬树脂复合物的制备工艺，紫外分光光度法测定度米芬含量。结果：温度为55 ℃、药物树脂质量比为9∶10、搅拌速度为500 r·min-1、搅拌时间为2 h为优化条件。结论：该优化工艺制备简单，成本低，效果好。
关键词 离子交换树脂；度米芬；均匀设计
中图分类号：TQ460.6
文献标识码：A
文章编号：1008-049X(2007)03-0261-02
Optimization of Preparation Formulation of Compound of
Ion-exchange Resins-Domiphen
Chen Liang, Tong Xu（Department of pharmacy, Daping Hospital, Field Operations Surgical
Institute.Third Military Medical University，Chongqing 400042,China）
ABSTRACT Objective: To study the preparation of compound of Ion-exchange resins Domiphen and the measure of max attach to resin.Method: The praparation process was optimized by uniform design.The content of domiphen was determinated by ultraciolet spectrophotometry.Result: The conditions of optimization process were as followes:temperature was 55 ℃,mix blend time was 2 h, the ratio of medicine to resin was 9∶10 and mix blend the speed was 500 r·min-1.Conclusion: The process is simple, the efficacy is good and costs is lowness.
KEY WORDS Ion exchange resins; Domiphen; Uniform design
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