修锐 王小虹 (沈阳军区大连疗养院 辽宁大连 116013)
摘 要 目的：考察枸橼酸阿奇霉素注射液的稳定性，并预测其室温贮存有效期。方法：用分光光度法测定枸橼酸阿奇霉素注射液含量；用初均速法预测其有效期。结果：本品在室温、高温条件下稳定；在光照下色泽变深，含量及pH有较明显变化。室温贮存有效期为11个月。结论：枸橼酸阿奇霉素注射液应闭光保存。
关键词 枸橼酸阿奇霉素注射液;有效期;初均速法
中图分类号：R942
文献标识码：A
文章编号：1008-049X(2007)03-0264-02
Prediction of Azithromycin Citrate
Injection Stability and Expiry Term
Xiu Rui, Wang Xiaohong(Dalian Sanatorium of Shenyang
Military District, Liaoning Dalian 116013,China)
ABSTRACT Objective: To study the stability of azithromycin citrate injection at room temperature as to predict its expiry term.Method: The content of azithromycin citrate injection was determined by UV spectrophotometry,the expiry term was predicted by initial average rate methods.Result: The content of azithromycin citrate injection changed markedly and its color darkened when it was exposed to sunlight at room temperature.Its expiry term under room temperature is 11 months.Conclusion: The azithr-omycin citrate injection should be kept in a dark place.
KEY WORDS Azithromycin citrate injection;Expiry term;Initial average rate method
参 考 文 献
1 中国药典［S］.2005年版.二部.附录85
2 中华人民共和国国家药品监督管理局标准（试行）［S］.WS-509(x-434)-2001
3 王艳萍,严晓鹏,薛万俐，等.氟罗沙星注射液稳定性及其有效期预测［J］.药学实践杂志，2004，22（1）：9-11
4 董亚,董海燕,姚鸿萍，等.金裕星注射液稳定性及其有效期预测［J］.中国现代应用药学，2003，20（1）：40-42
5 李庆德,李文玮.Excel在初均速法数据分析处理中的应用［J］.中国药师, 2005,4(1):32-33 资料来自:中国药师-专业站 |