金瓯 (浙江省药品检验所 浙江杭州 310004) 裘蛟恒 张昀 王新月 胡秋丽 (杭州中美华东制药有限公司)
摘 要 目的：考察注射用泮托拉唑钠和注射用奥美拉唑钠与氯化钠注射液配伍稳定性。方法：用HPLC法考察配伍前后泮托拉唑钠与奥美拉唑钠的含量变化，并观察配伍液的外观及pH变化。结果：注射用泮托拉唑钠和注射用奥美拉唑钠与0.9% 氯化钠注射液配伍后8 h内含量、pH及溶液外观均无明显变化。结论：注射用泮托拉唑钠和注射用奥美拉唑钠与氯化钠注射液配伍后在8 h内均稳定。
关键词 泮托拉唑钠；奥美拉唑钠；配伍稳定性
中图分类号：R942
文献标识码：A
文章编号：1008-049X(2007)04-0355-03
Study on Compatibility of Pantoprazole Sodium for Injection and Omeprazole Sodium for Injection with Sodium Chloride Injection
Jin Ou（Hangzhou Zhongmei Huadong Pharmaceutical Co.Ltd,Hangzhou 310004,China）Qiu Jiaoheng， Zhang Yun， Wang Xinyue， Hu Qiuli(Zhejiang Institute for Drug Control)
ABSTRACT Objective: To Study the compatibility of pantoprazole sodium for injection and omeprazole sodium for injection with Sodium Chloride Injection.Method:The change in content was determined by HPLC, and the change in appearance and pH was inspected.
Result: No obvious changes were noted in terms of contents, pH and appearances.Conclusion: The compatibility admixture of pantoprazole sodium for injection and omeprazole sodium for injection was stability with 0.9%NS within 8 hours.
KEY WORDS Pantoprazole sodium; Omeprazole sodium; Compatibility Stability
参 考 文 献
1 李军，部敬顺，张鉴.注射用泮托拉唑钠的稳定性考察［J］.中国药房，2005，16（21）：1655-1657
资料来自:中国药师-专业站 |