张俊松1 戚燕2 王晓利1 吴松2 (1.深圳职业技术学院 广东深圳 518055;2.中国医学科学院中国协和医科大学药物研究所)
摘 要 目的: 研究供静脉滴注和静脉推注的几种注射用奥美拉唑溶液的稳定性。方法：通过对溶液pH的测定和颜色变化情况的观察，对注射用奥美拉唑溶液进行配伍稳定性考察。结果：pH对注射用奥美拉唑溶液的稳定性有较大的影响。溶液pH大于8.5时较为稳定，而小于8时，易产生变色。
结论：pH是影响注射用奥美拉唑溶液稳定性的主要因素。供推注用粉针不适合用于静注，同样供静注粉针也不适合用于推注。
关键词 注射用奥美拉唑；配伍；稳定性
中图分类号：R944.1+1
文献标识码：A
文章编号：1008-049X(2007)04-0352-03
Study on the Stability of Omeprazole for Injection in different solutions
Zhang Junsong, Wang Xiaoli(Shenzhen Polytechnic college，Shenzhen 518055，China);
Qi Yan，Wu Song( Institute of Materia Medica，Peking Union Medical College，Chinese Academy of Medical Sciences)
ABSTRACT Objective: To study the stability of Omeprazole for intravenous injection and intravenous infusion.
Method:The pH and visual inspection were observed.Result: The pH could affect the stability of Omeprazol for injection greatly. The solution could keep relative stable at pH>8, and the solution was easy to change colour at pH<8.Conclusion: The pH could affect the stability of Omeprazol for injection greatly. Omeprazole for intravenous injection and intravenous infusion should not be replaced each other.
KEY WORDS Omeprazole for Injection; Compatibility of medicine; Stability
参 考 文 献
1 王景田,高晨. 注射用奥美拉唑钠稳定性及有关物质比较［J］.中国药学杂志,2003，12（38）:965-966
2 徐小微,张波等.6种市售奥美拉唑胶囊在模拟胃酸环境下的稳定性研究［J］.中国药学杂志,2003，5（38）:360-363
资料来自:中国药师-专业站 |