姜玲1 沈爱宗1 杜德才1 朱倩2 陈礼明1 （1.安徽省立医院药剂科 合肥 230001；2.安徽中医学院药学系2006届实习生)
摘 要 目的：探讨我院药品不良反应（ADR）发生的特点。方法：采用回顾性分析方法，对我院2002～2005年医务人员自愿呈报的990份ADRs报告进行分析。结果：我院ADRs报告数逐年增加；990例ADRs中涉及25类1174例药品，抗感染药占其中45.9%，其次为抗肿瘤药；抗感染药中喹喏酮类药品所占比例最高，为29.5%，头孢菌素类和青霉素类分别占26.7%、15.6%；ADR累及系统多为皮肤及附件，其次为消化系统；990例ADRs经过停药或治疗后，59.3%治愈，39.0%好转，仅0.5%有后遗症或死亡；进行关联性评价，肯定占13.0%，很可能占65.4%，可能占15.4%。结论：应继续加强ADR监测工作，降低漏报率，逐步提高ADR报告质量，尽量避免ADR的发生。
关键词 药品不良反应; 报告; 描述性分析
中图分类号：R951
文献标识码：A
文章编号：1008-049X(2007)07-0684-04
Study on 990 Cases of Adverse Drug Reaction
Jiang Ling1，Shen Aizong1， Du Decai1， Zhu Qian2，Chen Liming1 （Dept.of pharmacy, Anhui Provincial Hospital, Hefei 230001,China; 2. Department of Pharmacy, Anhui College of TCM)
ABSTRACT Objective: To explore the features of the adverse drug reaction (ADR) reports in our hospital.Method: A retrospective study was applied to quantitatively analyze the 990 ADR reports spontaneously reported by medical workers rfrom 2002 to 2005 in our hospital.Result: The number of ADRs were increased year by year.1174 kinds of 25 categories of drngs were suspected,45.9%of which was antiinfective agents,second was antitumor agents;29.5%of the antiinfective agents were quinolones,26.7%belonged to cephalosporins and 15.6%was penicillins；The most common displays of the ADRs was the lesion of skin and the appendages,second was diseases of the digestive system; 59.3%of them were cured,39.0% turned better, only0.5% had sequelae or died;13.0%of them were certain about causality assessment,65.4%probable,and 5.4%possible.Conclusion: It must be strengthen monitoring of ADR, decrease the percentage of failing to report，and improve the quality of ADR reports gradually.
KEY WORDS Adverse drug reaction;Report;Descriptive analysis
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