刘红 章雁 (湖北丽益科技有限公司 湖北省抗病毒药物重点实验室 武汉 430061) 王宗春 (武汉大学人民医院)
摘 要 目的：探讨O/W型咪喹莫特乳膏的最佳制备工艺。方法：采用正交法优选工艺。结果：最佳制备工艺组合为药物预先过200目筛处理，油水相组成比为25∶75，药物加入方式为加至油相中。结论：本制备工艺合理，制备出的乳膏质量稳定。
关键词 咪喹莫特；正交设计；乳膏; 制备工艺
中图分类号：R944.2+1
文献标识码：A
文章编号：1008-049X(2007)08-0798-03
Improvement of Preparation for Immiquimod Cream by Orthogonal Test
Liu Hong, Zhang Yan(Hubei Livscien pharm sci & Tech Co.,Ltd，Hubei key laboratory of antiviral drugs,Wuhan 430061,China)； Wang Zongchun(Renmin Hospital of Wuhan University)
ABSTRACT Objective: To improve the preparation of immiquimod cream.Method: The preparation were optimized by orthogonal test.
Result: The preparation optimization was that immiquimod should be sifted out by 200 mesh sieve and added into the oil phase，the proportion of oil phase to water phase was 27∶75.Conclusion: The preparation was reasonable and the quality of the cream was stable.
KEY WORDS Immiquimod; Cream; Orthogonal test; Preparation
参 考 文 献
1 毕殿洲.药剂学［M］.第4版.北京：人民卫生出版社，2002.369-381
2 Sauder DN,Skinner RB,Fox TL, et al.Topical immiquimod 5% cream as an effective treatment for extemal genital and perianal warts in different patient populations［J］. Sex Trofatter Dis，2003，30(2):124-128
3 彭燕，张洪，文为.正交试验法优选益宫散洁口服液水煎醇沉工艺［J］.中国药师，2006，9（10）：924-926 资料来自:中国药师-专业站 |