刘敏敏1 赖志辉2 黄亮3 (1. 广东省药品检验所 广州 510180；2.中山大学测试中心；3.广州市白云山制药总厂)
摘 要 目的：建立舒筋活血定痛丸的质量标准。方法：采用薄层色谱法（TLC）对制剂中的血竭、当归、延胡索、乳香进行鉴别；采用高效液相色谱法测定制剂中血竭素的含量。结果：在TLC中血竭、当归、延胡索、乳香能较好地被鉴别；HPLC法能准确测定出制剂中血竭素的含量, 血竭素在0.11～0.55 μg 范围内呈良好的线性关系,平均回收率为98.9%(RSD=1.73%)。结论：所建立的方法简单可行,能快速准确地对舒筋活血定痛丸进行鉴别和含量测定。
关键词 舒筋活血定痛丸；质量标准；薄层色谱；高效液相色谱法；血竭素
中图分类号：TQ460.7+2
文献标识码：A
文章编号：1008-049X(2007)08-0755-04
Study on Quality Criteria of Shujin Huoxue Dingtong Pills
Liu Minmin（Guangdong Institute for Drug Control, Guangzhou 510180，China）; Lai Zhihui（Sun YatSen University）;Huang Liang( Guangzhou Baiyunshan Pharmaceutical General Factory）
ABSTRACT Objective: To establish the quality Criteria of Shujin Huoxue Dingtong Granules.Method: Sanguis draconis, radix angelicae sinensis, rhizoma corydalis, frankincense in Shujin Huoxue Dingtong Granules were identified by TLC. Dracorhodin was determined by HPLC.Result: The characteristic identification by TLC was distict and highly specific. Tthe quantitative evaluation of radix angelicae sinensis had the linear range of 0.11μg～0.55 μg,the average recovery was 98.9％(RSD=1.73％).Conclusion: This method is accurate and can be used to control the quality of Shujin Huoxue Dingtong Granules.
KEY WORDS Huoxue Dingtong Granules; Quality criteria; TLC; HPLC; Dracorhodin
参 考 文 献
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4 张健萍，刘培. 活血止痛散的制备与质量控制［J］.中国药房，2005，16(13):992-993 资料来自:中国药师-专业站 |