刘起中1,3 李慧义2 杭太俊3 (1.临沂市药品检验所 山东临沂 276001；2.中国药品生物制品检定所 ；3.中国药科大学药物分析室)
摘 要 目的：建立检测中药制剂中非法添加化学药物成分氨茶碱、醋酸泼尼松的方法。方法：采用TLC法初筛，HPLC-DAD、LC-MS法确认，对非法掺入的化学药物进行定性鉴别，并以HPLC测定含量。结果： 4批中药制剂中分别检测到化学药物成分氨茶碱、醋酸泼尼松。结论：方法选择性强，准确可靠,可作为中药制剂中非法掺入化学药物成分氨茶碱、醋酸泼尼松的有效检验方法。
关键词 中药制剂；氨茶碱、醋酸泼尼松；薄层色谱法；高效液相色谱法；液相质谱
中图分类号：R927.1
文献标识码：A
文章编号：1008-049X(2007)08-0735-03
Identification of Chemical Compoents Illegally Mixed in Traditional Chinese Medicine Preparations
Liu Qizhong1,3，Li Huiyi2，Hang Taijun3（1.Shandong Linyi institute for drug control，Shandong, Linyi 276001, China; 2.National Institute for the Control of Pharmaceutical and Biological Products； 3.Department of Pharmaceutical Analysis, China Pharmaceutical University）
ABSTRACT Objective: To identify aminophylline, prednisone acetate mixed illeglly in traditional Chinese medicine(TCM) preparations.Method: Two Chemical components in TCM preparation were separated, identified and determined by TLC, LC-MS and HPLC.
Result: 4 batches of products were determined, which contained aminophylline and prednison acetate.Conclusion: The method is specific and sensitive, it can be used to detect the illegal TCM preparations.
KEY WORDS Traditional Chinese medicine(TCM) preparations; Aminophylline; Prednisone acetate; TLC, HPLC-DAD; LC-MS
参 考 文 献
1 张启明，尹华，黄海伟，等.检查中药中非法掺入枸橼酸西地那非的方法研究［J］.药物分析杂志，2002，22（4）：315-317
2 郭继芬，钟大放，陈笑艳.液相色谱食谱联用法鉴定9种皮质激素药物［J］.药学学报，1999，34（12）：928-932
资料来自:中国药师-专业站 |