刘丹 汤海峰 张三奇 (第四军医大学西京医院药剂科 西安 710032) 孟瑾 (解放军总医院) 丁愉 (解放军第214医院)
摘 要 目的：优化虎杖浓缩片的制备工艺，测定其中有效成分含量。方法：以崩解时限、吸湿性、外观作为评价指标对处方工艺进行筛选，制备虎杖浓缩片，用HPLC和差示分光光度法分别测定有效成分的含量。结果：最佳处方组成为每片含主药(总有效部位)0.195 g、乳糖0.08 g、微晶纤维素0.10g、羧甲基纤维素钠0.02 g、硬脂酸镁0.002 g。所制片剂硬度较好，外观光洁。白藜芦醇苷、白藜芦醇、大黄素、大黄素甲醚和总蒽醌等有效成分的含量测定结果符合规定。结论：本法处方合理，工艺简单，适用于工业化生产。
关键词 虎杖；片剂；制备工艺；含量测定
中图分类号：R283.64
文献标识码：A
文章编号：1008-049X(2007)10-0983-03
Preparing Technique and Determination of Concentrated Tablet of Polygonum Cuspidatum
Liu Dan, Tang Haifeng, Zhang Sanqi(Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China); Meng Jin (General Hospital of PLA); Ding Yu (No. 214th Hospital of PLA)
ABSTRACT Objective:To optimize the preparing technique of concentrated tablet of Polygonum cuspidatum and determine the contents of the effective ingredients.Method:The disassembly time limit, absorption and facies of the tablets were used as the primary screening indexes, the formulation was optimized,and the contents of the effective ingredients in the tablets were determined by HPLC and differential spectrophotometric methods.Result: The optimum formulation was composed of major medicine (total effective part of Polygonum cuspidatum) 0.195 g,lactose 0.08 g, MCC 0.10 g, CMC-Na0.02 g and magnesium stearate0.002 g.The tablets prepared were much better in hardness and facies.The determination results of the contents were accorded with the regulation. Conclusion:The method is reasonable,simple and suitable for industrialization.
KEY WORDS Polygonum cuspidatum; Tablet; Preparing Technique; Determination
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