刘明 王慧森 任孝德 李更生 (河南省中医药研究院 郑州 450004)
摘 要 目的：考察清开灵分散片的制备工艺和最优处方。方法：以分散时间为考察指标，采用正交设计试验对清开灵分散片处方进行筛选。
结果：以微晶纤维素为填充剂，微粉硅胶为助流剂，硬脂酸镁为润滑剂，3%的交联聚乙烯吡咯烷酮、6%的低取代羧丙基纤维素和5%的羧甲基淀粉钠为崩解剂，湿法制粒制备分散片。结论：本法研制的清开灵分散片处方合理，工艺可行。
关键词 清开灵分散片；分散时间；制备工艺
中图分类号：R283
文献标识码：A
文章编号：1008-049X(2007)11-1065-03
Study on Formulation and Preparation Technology of Qingkailing Dispersible Tablets
Liu Ming，Wang Huisen,Ren Xiaode,Li Gengsheng (Academy of Traditional Chinese Medicine of Henan Province，Zhengzhou 450004, China)
ABSTRACT Objective:To investigate the preparation technique and optimal formulation of Qingkailing dispersible tablets.Method:The formula of Qingkailing dispersible tablets was optimized in terms of disintegrating time by orthogonal design test.Result:The tablets was prepared by compressing moist granulation, the microcrystalling cellulose(MCC) as the bulking agent,the micro mist blangel as the glidant, the magnesium stearate (MS) as the lubricating agent and the crosslinking polyvinyl polypyrrolidone(3%,CPVPP),low displacement carboxyl propyl cellulose (6%, L-HPC) and sodium carboxymethyl starch (5%, CMS-Na) as the disintegrating agent were taken.Conclusion: The prescription and technology of Qingkailing dispersible tablets were reasonable and effective.
KEY WORDS Qingkailing dispersible tablets; Disintegration time; Processing technology
参 考 文 献
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3 陈燕军,臧琛,赵小妹,等.几种常用崩解剂与填充剂在中药分散片应用中的性能比较［Ｊ］.中国中药杂志,2002,27(8):580-583 资料来自:中国药师-专业站 |