程甦 （武汉科技大学医学院 武汉 430080） 屠庆年 （华中科技大学同济医学院中西医结合研究所）
摘 要 目的：通过观察卡托普利对2型糖尿病大鼠血管内皮功能的影响，探讨卡托普利对糖尿病微血管并发症的防治机制。方法：采用小剂量链脲佐菌素尾静脉注射加高糖高热量饲料喂养的方法建立2型糖尿病大鼠模型,将模型动物随机分为模型组(DM组）、卡托普利组(C组)(50 mg•kg-1•d-1), 另设正常对照组（N组）。药物干预治疗12周后, 检测各组动物空腹血糖（FBG）、总胆固醇(TC)、三酰甘油( TG)、高密度脂蛋白胆固醇(HDLC)、24 h尿微量白蛋白（Alb）、尿α1微球蛋白(α1-m) 及各组动物血浆中内皮素（ET1）、血栓素B2(TXB2)、６-酮前列腺环素(6-keto-PGF1α)、一氧化氮（NO）的表达水平。结果：与模型组相比，卡托普利组FBG 、TC 、TG、HDLC值未见明显改变，而Alb、α1-m量明显减少，血浆中ET1、TXB2的表达水平、TXB2/6-keto-PGF1α比值显著下降。结论：卡托普利能明显改善血管内皮功能 ，这可能是其防治糖尿病微血管并发症的机制之一。
关键词 卡托普利；2型糖尿病；血管内皮功能
中图分类号：R965.1
文献标识码：A
文章编号：1008-049X(2007)11-1060-03
Effect of Captopril on Vascular Endothelial Function in Type 2 Diabetic Rats
Cheng Su （Medical College of Wuhan University of Science and Technology，Wuhan 430080,China）;Tu Qingnian (Institute of Integrative Traditional & Western Medicine,Tongji Medical College,Huazhong University of Science & Technology)
ABSTRACT Objective: To investigate the effects of captopril on vascular endothelial function in type 2 diabetic rats and explore the protective mechanism of captopril in type 2 diabetic microangiopathy.Method: The murine with type 2 diabetes models were induced by the intravenous injection of a small dose of streptozotocin plus high fat and high caloric laboratory chow. Then modeled diabetic animals were divided into model group, catopril group. Normal rats fed with routine chow were designated as normal group. 12 weeks after treatment , the levels of fasting blood glucose (FBG),serum total cholesterol (TC),triglycerides (TG),high density lipoproteincholesterol (HDL-C),24 hours urinary microalbuminuria, urinary α1-microglobin, plasma endothelin，6-Ketoprostaglandin F1a,serum nitric oxide were determined.Result: Compared with model group, the levers of Alb、α1-m、ET-1、TXB2、TXB2/6-keto-PGF1α were markedly reduced in catopril group.Conclusion: It is suggested that catopril could protect vascular Endothelial Function in type 2 diabetes. That might be one of the protective mechanism in diabetic microangiopathy.
KEY WORDS Captopril; Type 2 Diabetes; Vascular endothelial function
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