冯瑞华 (丹东中心医院 辽宁丹东 118000） 李志强 苑振亭 （解放军230医院）
摘 要 目的：考察西尼地平对多索茶碱大鼠在体肠吸收的影响。方法：采用大鼠在体肠回流实验装置，用紫外分光光度法和HPLC法测定酚红、西尼地平和多索茶碱的含量。结果：西尼地平在大鼠全肠吸收速率常数为（2.24±0.01） h-1，多索茶碱在大鼠全肠吸收速率常数为（0.51±0.01） h-1，西尼地平与多索茶碱混合液在大鼠全肠吸收西尼地平吸,收速率常数（2.21±0.01） h-1、多索茶碱为（0.37±0.08） h-1。结论：西尼地平干扰了多索茶碱在小肠部位的吸收。
关键词 西尼地平；多索茶碱；吸收速率常数；小肠
中图分类号：R94
文献标识码：A
文章编号：1008-049X(2007)10-1058-03
Effect of the Intestinal Absorption Kinetics of Cilnidipine on Doxofylline in Rats
Feng Ruihua (Center Hospital of Dandong, Liaoning，Dandong 118000,China); Li Zhiqiang,Yuan Zhenting (No.230 Hospital of People’s Liberation Army)
ABSTRACT Objective:To study the effect of the intestinal absorption kinetics of cilnidipine on doxofylline in rats.Method: The intestine in rats was cannulated for in the equipment of recirculation. UV and HPLC were used to determine the concentrations of phenol red，cilnidipine and doxofylline respectively.Result: The absorption rate constants (Ka) from intestine of cilnidipine was （2.24±0.01）h-1and doxofylline was （0.51±0.01）h-1 ,Ka of cilnidipine and doxofylline in rats was （2.21±0.01）h-1and （0.37±0.08）h-1 respectively.Conclusion: Cilnidipine disturbed the intestinal absorption of doxofylline in rats.
KEY WORDS Cilnidipine; Doxofylline; Absorption rate constant; Intestine
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