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不同来源β-环糊精对薄荷脑包合率的影响研究
Effects of β-Cyclodextrin from Different Sources on Inclusion Rate of Menthol
投稿时间:2017-01-03  修订日期:2017-03-01
DOI:
中文关键词:  β-环糊精  薄荷脑  包合率  薄层色谱法  粉末X射线衍射法  气相色谱法
英文关键词:β-Cyclodextrin  Menthol  Inclusion rate  TLC  Powder X-ray diffraction  GC
基金项目:广东省医学科学技术研究基金项目(编号:A2016363);2016年国家药品抽验项目
作者单位
靳贵英 广东省药品检验所 广州 510180 
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中文摘要:
      摘 要 目的:比较不同来源的β-环糊精(β-CD)对薄荷脑的包合率。方法: 采用研磨法制备β 环糊精 薄荷脑包合物,通过TLC法、粉末X射线衍射法和GC法对包合物进行鉴定和表征。粉末X射线衍射分析条件:Cu Kα辐射石墨单色器;管压为40 kV,管流为40 mA;扫描范围为3~35°;扫描步长为0.02°,扫描速率为5°·min-1。GC色谱条件:采用Agilent DB wax毛细管色谱柱(30 m×0.53 mm,1.0 μm),柱温为120℃,进样口温度为250℃,采用火焰离子化检测器(FID),检测器温度为250℃;分流比为10∶1。结果: TLC和粉末X射线衍射试验均证明包合物的形成。进口和国产β CD对薄荷脑的包合率分别为47.9%和25.0%。结论:本试验所采用的方法简便、快速、准确,可用于测定不同来源β-CD对薄荷脑的包合能力。结果表明进口β-CD的包合效果优于国产β-CD。
英文摘要:
      ABSTRACT Objective: To compare the inclusion rate of menthol with β-cyclodextrin (β-CD) from different sources. Methods: β Cyclodextrin menthol inclusion complexes were prepared by a grinding method. The inclusion compound was verified by thin layer chromatography (TLC), powder X ray diffraction (PXRD) and gas chromatography (GC). The optimized conditions of PXRD were as follows: the graphite monochromator was Cu Kα, the voltage was 40 kV, the current was 40 mA, the 2θ scanning range was from 3° to 35°, the scanning step was 0.02° and the scanning rate was 5°·min-1. The optimized conditions of GC were as follows: an Agilent DB wax capillary column, the column temperature was 120°, the inlet temperature was 250°, the detector temperature was 250° and the split ratio was 10∶1. Results:The results of TLC and PXRD proved the formation of inclusion complexes. The inclusion rate of menthol with β-CD from home and abroad was 25% and 47.9%, respectively. Conclusion:The method is simple, accurate and rapid, which can be used to determine the inclusion rate of β-CD from different sources. The results show that the inclusion effect of imported β-CD is better than that of domestic β-CD.
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