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吲哚美辛肠溶滴丸分散状态的表征
Characterization of Indomethacin Enteric coated Dropping Pills
投稿时间:2016-12-04  修订日期:2017-01-07
DOI:
中文关键词:  吲哚美辛  肠溶  滴丸  表征
英文关键词:Indometacin  Enteric coated  Dropping pills  Characterization
基金项目:
作者单位
王军1方小华1胡拥军2 1.武汉大学人民医院药学部 武汉 4300602.湖北省妇幼保健院药剂科 
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中文摘要:
      摘 要 目的:考察吲哚美辛(IDM)肠溶滴丸中IDM存在的状态及与基质聚乙二醇6000(PEG 6000)的相互作用。方法: 分别采用差示扫描量热法(DSC)、红外光谱法(IR)、X-射线衍射法及扫描电镜(SEM)观察对IDM、PEG 6000、两者的物理混合物及IDM肠溶滴丸进行研究。结果: DSC图谱中,IDM肠溶滴丸在164℃处的吸热峰消失,而57℃处的PEG 6000吸热峰发生了前移;IR图谱中,IDM肠溶滴丸中IDM的羰基伸缩振动峰消失,而在1 680 cm-1处出现了新峰;X-射线衍射图谱中,IDM肠溶滴丸无衍射峰存在;SEM下IDM以更细小的状态分布于基质中。
英文摘要:
      ABSTRACT Objective: To study the status of indomethacin (IDM) in IDM enteric coated dropping pills and its interaction with PEG 6000. Methods: IDM, PEG 6000, their physical mixture and IDM enteric coated dropping pills were respectively studied by DSC, IR, X-ray diffraction and SEM. Results:In the map of DSC, the endothermic peak of IDM enteric coated dropping pills disappeared at 164℃, and the endothermic peak of PEG 6000 at 57℃ shifted forward. In the map of IR, the carbonyl stretching vibration peak of IDM in IDM enteric coated dropping pills disappeared, and a new peak appeared at 1 680 cm-1. In the map of X ray diffraction, there was no diffraction peak in IDM enteric coated dropping pills. SEM showed the morphology of IDM in the base was much smaller than that of IDM raw material. Conclusion:IDM in IDM enteric coated dropping pills is dispersed in the matrix with an amorphous or molecular form, and there is hydrogen bond between IDM and PEG 6000.
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