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中药联合奥沙利铂治疗癌症的增效减毒作用概述
Inreasing Efficacy and Decreasing foxicity of Chinese Medicine Combined with Oxaliplatin in the Treatment of Cancer
投稿时间:2017-05-15  修订日期:2017-05-27
DOI:
中文关键词:  奥沙利铂  中药  联合使用  增效  减毒
英文关键词:Oxaliplatin  Chinese medicine  Combinahon  Increasing efficacy  Decreasing foxicity
基金项目:
作者单位
张媛凤1 史拓1 谢鸣1  李承龙2 1.北京中医药大学方剂学系 北京 1000292.山西医科大学公共卫生学院 
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中文摘要:
      摘 要奥沙利铂是继顺铂和卡铂之后的第三代铂类抗癌药物,虽其临床消化道反应、骨髓抑制及肾毒性的发生有所缓减,但外周神经毒性反应仍很突出,有效预防或减少其不良反应是临床面对的重要课题。大量研究表明,奥沙利铂与中药联合运用,能有效降低不良反应及提高疗效。本文拟从临床和实验研究方面,对近些年来中药联合奥沙利铂治疗癌症的增效减毒作用的研究报道进行述评,以为此类药物及其化疗方案的运用提供参考。
英文摘要:
      ABSTRACTOxaliplatin, a third generation platinum based compound with significant activity against tumors, has become pivotal for the therapy of cancer after cisplatin and carboplatin. The digestive tract reaction, myelosuppression and nephrotoxicity have been alleviated, however, oxaliplatin induced neurotoxicity occurs prominently. Therefore, how to effectively eliminate and prevent chemotherapy induced side and toxic effects becomes a great challenge for oncologists. plenty of evidence has hinted that combination of Chinese herbal medicine and oxaliplatin can not only reduce the toxicity, but also improve the actual efficacy, clinical research and experimental researches on increasing off cacy and decresing foxcity of Chinese herbal medicine combined with oxali platin in the treatment of cancer in recent years were rewewed.to provide reference for the clinical use of oxaliplatin based chemotherapy regimen.
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