• 国家科技部中国科技论文统计源期刊
  • 中国科技核心期刊
  • WHO西太平洋地区医学索引(WPRIM)收录期刊
  • 美国《化学文摘》收录期刊
不同方法对氨基比林纯度联合定值及不确定度评定
Valuation and Uncertainty Evaluation of the Purity Determination of Aminopyrine by Different Methods
投稿时间:2017-12-24  修订日期:2018-01-05
DOI:
中文关键词:  氨基比林  纯度  不确定度  高效液相色谱法  酸碱滴定法
英文关键词:Aminopyrine  Purity  Uncertainty  HPLC  Acid base titration
基金项目:河北省食品药品监督管理局2014年度食品药品安全科技项目计划(编号:PT2014007)
作者单位
郭永辉 闫凯 韩学静 河北省药品检验研究院 石家庄 050011 
摘要点击次数: 374
全文下载次数: 274
中文摘要:
      摘 要 目的:采用两种不同原理方法对氨基比林纯度联合定值,并建立其不确定度评定方法。方法: 采用高效液相色谱法(HPLC)与酸碱滴定法对氨基比林纯度进行测定,并依据标准物质技术规范及相关计量技术规范要求,对两种不同原理方法测定过程的不确定度进行系统分析。结果:采用HPLC与酸碱滴定法联合测定氨基比林纯度的标准值及其不确定度为99.66%±0.08%(k=2,P=0.95)。结论:采用HPLC与酸碱滴定法联合测定氨基比林纯度及不确定度评定结果准确可靠,避免了采用一种技术带来的分析方法缺陷,有利于提高氨基比林的质量评价与控制水平,同时对氨基比林纯度标准物质的研制提供科学依据。
英文摘要:
      ABSTRACT Objective: To study the valuation and uncertainty evaluation of the purity determination of aminopyrine by two different principle methods. Methods: According to Technical Norm of Primary Reference Material and Technical Norm of Measurement, HPLC and acid base titration were selected for studying the valuation of the purity determination of aminopyrine, and the uncertainty evaluation of the two different principle methods was systematically evaluated. Results: By using the two different principle methods, the standard value and uncertainty of aminopyrine content was 99.66%±0.08%(k=2,P=0.95). Conclusion:The valuation and uncertainty evaluation of the purity determination of aminopyrine by using HPLC and acid base titration are accurate and reliable, which can avoid the defects by using single analysis method, and is helpful to improve the level of quality evaluation and control of aminopyrine. The study provides scientific basis for the development of aminopyrine purity reference materials.
查看全文  查看/发表评论  下载PDF阅读器
关闭